Anti-RUNX2

0.5 mg/ml with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide. RUNX (runt-related transcription factor) proteins are a family of transcription factors involved in many different biological systems, including cell differentiation and cancer. RUNX2 is an essential factor in bone development, acting as a scaffold protein for nucleic acids and regulatory factors involved in skeletal gene expression. It is also involved in cancer cell movement, activating factors involved in the metastasis of prostate and breast cancer cells to bone. Protein function: Transcription factor involved in osteoblastic differentiation and skeletal morphogenesis. Essential for the maturation of osteoblasts and both intramembranous and endochondral ossification. CBF binds to the core site, 5'- PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, osteocalcin, osteopontin, bone sialoprotein, alpha 1(I) collagen, LCK, IL-3 and GM-CSF promoters. In osteoblasts, supports transcription activation: synergizes with SPEN/MINT to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE). Inhibits KAT6B-dependent transcriptional activation. [The UniProt Consortium]