Anti-RUNX2

Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
ARG57938.100	100 µl		-	-	6 - 14 business days*		658.00€

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Protein function: Transcription factor involved in osteoblastic differentiation and skeletal... more

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Product information "Anti-RUNX2"

Protein function: Transcription factor involved in osteoblastic differentiation and skeletal morphogenesis (PubMed:28505335, PubMed:28738062, PubMed:28703881). Essential for the maturation of osteoblasts and both intramembranous and endochondral ossification. CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, osteocalcin, osteopontin, bone sialoprotein, alpha 1(I) collagen, LCK, IL-3 and GM-CSF promoters. In osteoblasts, supports transcription activation: synergizes with SPEN/MINT to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE). Inhibits KAT6B-dependent transcriptional activation. [The UniProt Consortium]

Keywords:	Anti-AML3, Anti-OSF-2, Anti-RUNX2, Anti-CBF-alpha-1, Anti-PEA2-alpha A, Anti-PEBP2-alpha A, Anti-Oncogene AML-3, Anti-Acute myeloid leukemia 3 protein, Anti-Runt-related transcription factor 2, Anti-Core-binding factor subunit alpha-1
Supplier:	Arigo Biolaboratories
Supplier-Nr:	ARG57938

Properties

Application:	WB
Antibody Type:	Polyclonal
Conjugate:	No
Host:	Rabbit
Species reactivity:	human, mouse
Immunogen:	Recombinant fusion protein corresponding to aa. 242-521 of Human RUNX2 (NP_001019801.3)
MW:	56 kD
Format:	Affinity Purified