Cookie preferences
This website uses cookies, which are necessary for the technical operation of the website and are always set. Other cookies, which increase the comfort when using this website, are used for direct advertising or to facilitate interaction with other websites and social networks, are only set with your consent.
Configuration
Technically required
These cookies are necessary for the basic functions of the shop.
"Allow all cookies" cookie
"Decline all cookies" cookie
CSRF token
Cookie preferences
Currency change
Customer-specific caching
FACT-Finder tracking
Individual prices
Selected shop
Session
Comfort functions
These cookies are used to make the shopping experience even more appealing, for example for the recognition of the visitor.
Note
Show the facebook fanpage in the right blod sidebar
Statistics & Tracking
Affiliate program
Conversion and usertracking via Google Tag Manager
Track device being used
| Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
|---|---|---|---|---|---|---|---|
| ABS-KC-3165.50 | 50 µl | - | - |
Request delivery time estimate |
206.00€
|
||
| ABS-KC-3165.100 | 100 µl | - | - |
Request delivery time estimate |
295.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Protein function: Activator of the canonical Wnt signaling pathway by acting as a ligand for... more
Product information "Anti-RSPO3"
Protein function: Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors, which acts as a key regulator of angiogenesis. Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Also regulates the canonical Wnt/beta-catenin-dependent pathway and non- canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. Acts as a ligand for frizzled FZD8 and LRP6. May negatively regulate the TGF-beta pathway (PubMed:21727895, PubMed:21909076, PubMed:22615920). Acts as a key regulator of angiogenesis by controlling vascular stability and pruning: acts by activating the non-canonical Wnt signaling pathway in endothelial cells (PubMed:21727895, PubMed:21909076, PubMed:22615920). Can also amplify Wnt signaling pathway independently of LGR4-6 receptors, possibly by acting as a direct antagonistic ligand to RNF43 and ZNRF3 (PubMed:29769720). [The UniProt Consortium]
| Keywords: | Anti-R-spondin-3, Anti-Protein with TSP type-1 repeat, Anti-hPWTSR, Anti-Roof plate-specific spondin-3, Anti-hRspo3, Anti-Thrombospondin type-1 domain-containing protein 2, RSPO3 Antibody |
| Supplier: | Absea |
| Supplier-Nr: | KC-3165 |
Properties
| Application: | IP |
| Antibody Type: | Monoclonal |
| Clone: | 15C3 |
| Conjugate: | No |
| Host: | Mouse |
| Species reactivity: | human, mouse |
| Immunogen: | Recombinant human RSPO3 |
| Format: | Solution |
Database Information
| KEGG ID : | K23098 | Matching products |
| UniProt ID : | Q9BXY4 | Matching products |
| Gene ID : | GeneID 84870 | Matching products |
Handling & Safety
| Storage: | -20°C (avoid repeat freezing and thawing cycles) |
| Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
You will get a certificate here
Viewed