Anti-RSPO2 / R-spondin-2

In 1X PBS, pH 7.4, with 0.09% sodium azide. RSPO2 is a member of the R-spondin family of proteins, which are known for their ability to regulate the Wnt signaling pathway. This pathway plays a crucial role in cell proliferation, differentiation, and stem cell maintenance. RSPO2 specifically has been shown to enhance Wnt signaling, leading to increased cell growth and tissue regeneration. Research on RSPO2 is still in its early stages, but some studies have already shown promising results. For example, a study published in the journal Cell Stem Cell found that RSPO2 can enhance the regenerative capacity of intestinal stem cells, potentially leading to new treatments for diseases like inflammatory bowel disease. Protein function: Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors. Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway (PubMed:21727895, PubMed:21909076, PubMed:22615920). During embryonic development, plays a crucial role in limb specification, amplifying the Wnt signaling pathway independently of LGR4-6 receptors, possibly by acting as a direct antagonistic ligand to RNF43 and ZNRF3, hence governing the number of limbs an embryo should form (PubMed:29769720). [The UniProt Consortium]