Anti-RSPO1 / R spondin 1

Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
ARG41323.50	50 µg		-	-	6 - 14 business days*		567.00€

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Protein function: Activator of the canonical Wnt signaling pathway by acting as a ligand for... more

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Product information "Anti-RSPO1 / R spondin 1"

Protein function: Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors (PubMed:29769720). Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. Acts as a ligand for frizzled FZD8 and LRP6. May negatively regulate the TGF-beta pathway. Has a essential roles in ovary determination. Regulates Wnt signaling by antagonizing DKK1/KREM1-mediated internalization of LRP6 through an interaction with KREM1 (PubMed:17804805). [The UniProt Consortium]

Keywords:	Anti-RSPO1, Anti-hRspo1, Anti-R-spondin-1, Anti-Roof plate-specific spondin-1
Supplier:	Arigo Biolaboratories
Supplier-Nr:	ARG41323

Properties

Application:	IHC (paraffin), WB
Antibody Type:	Polyclonal
Conjugate:	No
Host:	Rabbit
Species reactivity:	human, mouse (Expected: rat)
Immunogen:	A 16 amino acid synthetic peptide within the first 50 amino acids of Human RSPO1
MW:	29 kD
Format:	Antigen Affinity Purified