Anti-RSPO1

Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
ATA-HPA046154.25	25 µl		-		7 - 10 business days*		369.00€
ATA-HPA046154.100	100 µl		-		7 - 10 business days*		491.00€

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Protein function: Activator of the canonical Wnt signaling pathway by acting as a ligand for... more

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Product information "Anti-RSPO1"

Protein function: Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors (PubMed:29769720). Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Also regulates the canonical Wnt/beta-catenin- dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. Acts as a ligand for frizzled FZD8 and LRP6. May negatively regulate the TGF-beta pathway. Has a essential roles in ovary determination. Regulates Wnt signaling by antagonizing DKK1/KREM1- mediated internalization of LRP6 through an interaction with KREM1 (PubMed:17804805). [The UniProt Consortium] Buffer: 40% glycerol and PBS (pH 7.2). 0.02% sodium azide is added as preservative. Highest antigen sequence identity to mouse: 90% and to rat: 90%

Keywords:	Anti-RSPO1, Anti-hRspo1, Anti-R-spondin-1, Anti-Roof plate-specific spondin-1
Supplier:	Atlas Antibodies
Supplier-Nr:	HPA046154

Properties

Application:	IHC
Antibody Type:	Polyclonal
Conjugate:	No
Host:	Rabbit
Species reactivity:	human
Immunogen:	Recombinant Protein Epitope Signature Tag (PrEST) antigen sequence: CKEGLYLHKG RCYPACPEGS SAANGTMECS SPAQCEMSEW SPWGPCSKKQ QLCGFRRGSE ERTRRVLHA (ATA-APrEST77057)