Anti-RRP6L1

Make to order. Production time: 70-80 business days. Deliverables: 1. 200 µg antigen (used as positive control), 2. 1 ml pre-immune serum (used as negative control) , 3. Rabbit polyclonal antibody, antigen affinity purified. Quality Guarantee: 1. Antibody purity > 90% confirmed by SDS-PAGE, 2. Antibody titer > 1: 64,000 confirmed by ELISA, 3. WB positive with the immunogen protein (not applicable for synthetic peptide). Applications: ELISA, WB (positive for the recombinant immunogen protein/peptide). Buffer: Preservative: 0.03% Proclin 300, Constituents: 50% Glycerol, 0.01M PBS, pH 7.4. Protein function: Acts as an important epigenetic regulator through multiple silencing mechanisms (PubMed:23555312, PubMed:24719467, PubMed:24726328, PubMed:25211139). Involved in transcriptional gene silencing (TGS). Plays a role for DNA methylation in the RNA-directed DNA methylation (RdDM) pathway. Contributes to the methylation status of the retrotransposon SN1. Required for DNA methylation only at a subset of RdDM target loci (PubMed:24719467). Plays a regulatory role in RdDM through retention of non-coding RNAs (ncRNAs) in normal cells. Helps to retain Pol V-transcribed RNAs in chromatin to enable their scaffold function and is required for genome-wide Pol IV-dependent siRNA (24 nt siRNA) production that may involve retention of Pol IV transcripts (PubMed:24726328). Involved in association with RRP6L2 in the silencing of the solo LTR locus. Controls levels of ncRNAs from the solo LTR locus. Seems to function independently of the RdDM pathway (PubMed:23555312). Functions redundantly with RRP6L2 in the regulation of FLC locus. Participates in the maintenance of trimethylated 'Lys-27' (H3K27me3) at FLC locus via the regulation of antisense long non-coding RNAs (lncRNAs) and the regulation of diverse antisense RNAs derived from the FLC locus (PubMed:25211139). Seems not involved in the exosomal RNA degradation (PubMed:24726328, PubMed:25211139). Can complement the growth defect of a yeast mutant lacking RRP6 exonuclease (PubMed:18285452). [The UniProt Consortium]