Anti-RPC2

Item number Size Datasheet Manual SDS Delivery time Quantity Price
A301-855A-T 20 µl (2 blots) -

3 - 9 business days*

131.00€
A301-855A-M 100 µl (10 blots) -

3 - 9 business days*

313.00€
A301-855A 100 µl (20 µg) -

3 - 9 business days*

465.00€
 
Protein function: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using... more
Product information "Anti-RPC2"
Protein function: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol III is composed of mobile elements and RPC2 is part of the core element with the central large cleft and probably a clamp element that moves to open and close the cleft. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway. [The UniProt Consortium]
Keywords: Anti-C128, Anti-POLR3B, EC=2.7.7.6, Anti-RNA polymerase III subunit C2, Anti-DNA-directed RNA polymerase III subunit B, Anti-DNA-directed RNA polymerase III subunit RPC2, Anti-DNA-directed RNA polymerase III 127.6 kDa polypeptide
Supplier: Bethyl Laboratories
Supplier-Nr: A301-855A

Properties

Application: WB, IP, IHC
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Reactivity: Human (Expected: Bovine, Dog, Horse, Pig, Panda, Orangutan, Rhesus Monkey, Gorilla, Chimpanzee, Duckbill Platypus, Tasmanian Devil, White-tufted-ear Marmoset, Crab-eating Macaque, African Elephant, Naked Mole Rat, Northern White-cheeked Gibbon)
Immunogen: synthetic peptide. The epitope recognized by A301-855A-T maps to a region between residue 1083 and 1133 of human RNA polymerase III subunit C2 using the numbering given in entry NP_060552.3 (GeneID 55703).
Format: Antigen Affinity Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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