Anti-ROBO1

Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
ATA-HPA074461.25	25 µl		-		7 - 10 business days*		300.00€
ATA-HPA074461.100	100 µl		-		7 - 10 business days*		421.00€

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Protein function: Receptor for SLIT1 and SLIT2 that mediates cellular responses to molecular... more

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Product information "Anti-ROBO1"

Protein function: Receptor for SLIT1 and SLIT2 that mediates cellular responses to molecular guidance cues in cellular migration, including axonal navigation at the ventral midline of the neural tube and projection of axons to different regions during neuronal development (PubMed:10102268, PubMed:24560577). Interaction with the intracellular domain of FLRT3 mediates axon attraction towards cells expressing NTN1 (PubMed:24560577). In axon growth cones, the silencing of the attractive effect of NTN1 by SLIT2 may require the formation of a ROBO1-DCC complex. Plays a role in the regulation of cell migration via its interaction with MYO9B, inhibits MYO9B-mediated stimulation of RHOA GTPase activity, and thereby leads to increased levels of active, GTP-bound RHOA (PubMed:26529257). May be required for lung development. [The UniProt Consortium] Buffer: 40% glycerol and PBS (pH 7.2). 0.02% sodium azide is added as preservative. Highest antigen sequence identity to mouse: 97% and to rat: 96%

Keywords:	Anti-DUTT1, Anti-ROBO1, Anti-H-Robo-1, Anti-Roundabout homolog 1, Anti-Deleted in U twenty twenty
Supplier:	Atlas Antibodies
Supplier-Nr:	HPA074461

Properties

Application:	ICC
Antibody Type:	Polyclonal
Conjugate:	No
Host:	Rabbit
Species reactivity:	human
Immunogen:	Recombinant Protein Epitope Signature Tag (PrEST) antigen sequence: PNTGNNHNDC SISCCTAGNG NSDSNLTTYS RPADCIANYN NQLDNKQTNL MLPESTVYGD VDLSNKINEM KTFNSPNLKD GRFVNPSGQP TPYATTQLIQ SNLSNNMNNG SGD (ATA-APrEST94410)