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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
R2994-01.200 | 200 µl | - | - |
3 - 19 business days* |
688.00€
|
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You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Proteins that directly bind to nascent RNA polymerase II transcripts, the heterogenous nuclear... more
Product information "Anti-RNP M1-M4 (Nuclear Ribonucleoprotein, nRNP, hnRNP), clone 3C181"
Proteins that directly bind to nascent RNA polymerase II transcripts, the heterogenous nuclear ribonucleoproteins (hnRNPs), play an important role in both transcript-specific packaging and alternative splicing of pre-mRNAs. A group of abundant hnRNPs, the M1-M4 proteins, appear as a cluster of four proteins. The M proteins are pre-mRNA binding proteins in vivo, and they bind avidly to poly (G) and poly (U) RNA homopolymers in vitro. M proteins are members of the ribonucleoprotein consensus sequence family of RNA-binding proteins with greatest similarity to a hypothetical RNA-binding protein from Saccharomyces cerevisiae. The M proteins also possess an unusual hexapeptide-repeat region rich in methionine and arginine residues (MR repeat motif) that resembles a repeat in the 64kD subunit of cleavage stimulation factor, which is involved in 3-end maturation of pre-mRNAs. Proteins immunologically related to M exist in divergent eukaryotes ranging from human to yeast. Applications: Suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence/Immunocytochemistry and Immunoprecipitation. Other applications have not been tested. Recommended Dilutions: Western Blot: 1:500. Detects a band at 64-68kD using HeLa cell lysate., Immunoprecipitation: 1:10-1:500, Immunohistochemistry (Frozen/Paraffin): 1:10-1:2000, Immunofluorescence (IC): 1:10-1:2000, Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Keywords: | Anti-HNRPM, Anti-HNRNPM, Anti-hnRNP M, Anti-Heterogeneous nuclear ribonucleoprotein M |
Supplier: | United States Biological |
Supplier-Nr: | R2994-01 |
Properties
Application: | ICC, IF, IHC, IP, WB |
Antibody Type: | Monoclonal |
Clone: | 3C181 |
Conjugate: | No |
Host: | Mouse |
Species reactivity: | bovine, cat, human, mouse, swine, rabbit, rat |
Format: | Ascites |
Database Information
KEGG ID : | K12887 | Matching products |
UniProt ID : | P52272 | Matching products |
Gene ID | GeneID 4670 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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