Anti-RNF20

Polyclonal Antibody against Human RNF20, Gene description: ring finger protein 20, Alternative Gene Names: BRE1, BRE1A, FLJ11189, FLJ20382, hBRE1, KAIA2779, Validated applications: ICC, Uniprot ID: Q5VTR2, Storage: Store at +4°C for short term storage. Long time storage is recommended at -20°C. Protein function: Component of the RNF20/40 E3 ubiquitin-protein ligase complex that mediates monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1). H2BK120ub1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation (H3K4me and H3K79me, respectively). It thereby plays a central role inb histone code and gene regulation. The RNF20/40 complex forms a H2B ubiquitin ligase complex in cooperation with the E2 enzyme UBE2A or UBE2B, reports about the cooperation with UBE2E1/UBCH are contradictory. Required for transcriptional activation of Hox genes. Recruited to the MDM2 promoter, probably by being recruited by p53/TP53, and thereby acts as a transcriptional coactivator. Mediates the polyubiquitination of isoform 2 of PA2G4 in cancer cells leading to its proteasome-mediated degradation. [The UniProt Consortium] Mouse gene identity: 98% Rat gene identity: 98%