Anti-RNF2

Anti-RNF2
Item number Size Datasheet Manual SDS Delivery time Quantity Price
A302-869A-T 20 µl (2 blots) -

3 - 9 business days*

131.00€
A302-869A-M 100 µl (10 blots) -

3 - 9 business days*

313.00€
A302-869A 100 µl (100 µg) -

3 - 9 business days*

465.00€
 
Protein function: E3 ubiquitin-protein ligase that mediates monoubiquitination of 'Lys-119' of... more
Product information "Anti-RNF2"
Protein function: E3 ubiquitin-protein ligase that mediates monoubiquitination of 'Lys-119' of histone H2A (H2AK119Ub), thereby playing a central role in histone code and gene regulation (PubMed:15386022, PubMed:16359901, PubMed:25519132, PubMed:21772249, PubMed:25355358, PubMed:26151332). H2AK119Ub gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. May be involved in the initiation of both imprinted and random X inactivation. Essential component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development (PubMed:16359901, PubMed:26151332). PcG PRC1 complex acts via chromatin remodeling and modification of histones, rendering chromatin heritably changed in its expressibility (PubMed:26151332). E3 ubiquitin-protein ligase activity is enhanced by BMI1/PCGF4 (PubMed:21772249). Acts as the main E3 ubiquitin ligase on histone H2A of the PRC1 complex, while RING1 may rather act as a modulator of RNF2/RING2 activity (Probable). Association with the chromosomal DNA is cell-cycle dependent. In resting B- and T-lymphocytes, interaction with AURKB leads to block its activity, thereby maintaining transcription in resting lymphocytes. [The UniProt Consortium]
Keywords: Anti-RNF2, Anti-BAP1, Anti-RING1b, Anti-Protein DinG, Anti-RING finger protein 2, Anti-RING finger protein 1B, Anti-RING finger protein BAP-1, Anti-HIP2-interacting protein 3, Anti-E3 ubiquitin-protein ligase RING2
Supplier: Bethyl Laboratories
Supplier-Nr: A302-869A

Properties

Application: WB, IP, IHC, ChIP-Seq
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Reactivity: Human, Mouse (Expected: Rat, Orangutan)
Immunogen: synthetic peptide. The epitope recognized by A302-869A-T maps to a region between residue 150 and 200 of human Ring Finger Protein 2 using the numbering given in entry NP_009143.1 (GeneID 6045).
Format: Antigen Affinity Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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