Anti-RNASEH2A

Item number Size Datasheet Manual SDS Delivery time Quantity Price
E-AB-65212.60 60 µl -

7 - 16 business days*

198.00€
E-AB-65212.120 120 µl -

7 - 16 business days*

317.00€
E-AB-65212.200 200 µl -

7 - 16 business days*

525.00€
 
The protein encoded by this gene is a component of the heterotrimeric type II ribonuclease H... more
Product information "Anti-RNASEH2A"
The protein encoded by this gene is a component of the heterotrimeric type II ribonuclease H enzyme (RNAseH2). RNAseH2 is the major source of ribonuclease H activity in mammalian cells and endonucleolytically cleaves ribonucleotides. It is predicted to remove Okazaki fragment RNA primers during lagging strand DNA synthesis and to excise single ribonucleotides from DNA-DNA duplexes. Mutations in this gene cause Aicardi-Goutieres Syndrome (AGS), a an autosomal recessive neurological disorder characterized by progressive microcephaly and psychomotor retardation, intracranial calcifications, elevated levels of interferon-alpha and white blood cells in the cerebrospinal fluid. Protein function: Catalytic subunit of RNase HII, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging- strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes. [The UniProt Consortium]
Keywords: Anti-AGS4, Anti-RNASEHI, Anti-RNASEH2A, Anti-RNase H(35), EC=3.1.26.4, Anti-RNase H2 subunit A, Anti-RNase HI large subunit, Anti-Ribonuclease H2 subunit A, Anti-Ribonuclease HI subunit A, Anti-Ribonuclease HI large subunit, RNASEH2A Polyclonal Antibody
Supplier: Elabscience
Supplier-Nr: E-AB-65212

Properties

Application: WB
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Species reactivity: rat
Immunogen: Recombinant protein of human RNASEH2A

Handling & Safety

Storage: -20°C
Shipping: 4°C (International: -20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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