Anti-Recombinant Tensin 4, clone R06-1F3

May be involved in cell migration, cartilage development and in linking signal transduction pathways to the cytoskeleton . May promote apoptosis, via its cleavage by caspase-3. Protein function: Promotes EGF-induced cell migration by displacing tensin TNS3 from the cytoplasmic tail of integrin ITGB1 which results in dissociation of TNS3 from focal adhesions, disassembly of actin stress fibers and initiation of cell migration (PubMed:17643115). Suppresses ligand-induced degradation of EGFR by reducing EGFR ubiquitination in the presence of EGF (PubMed:23774213). Increases MET protein stability by inhibiting MET endocytosis and subsequent lysosomal degradation which leads to increased cell survival, proliferation and migration (PubMed:24814316). [The UniProt Consortium]