Anti-Recombinant RAP1A+RAP1B, clone A459

Rap1 is a member of the Ras family of small GTPases. It undergoes a change in conformational state and activity, depending on whether it is bound to GTP or GDP. This protein is activated by several types of guanine nucleotide exchange factors (GEFs), and inactivated by two groups of GTPase-activating proteins (GAPs). The activation status of Rap1 is therefore affected by the balance of intracellular levels of GEFs and GAPs. This protein regulates signaling pathways that affect cell proliferation and adhesion, and may play a role in tumor malignancy.