Anti-Recombinant PPM1A/PP2CA, clone 8C5

Protein phosphatase 1A (PPM1A/PP2CA) is an enzyme belonging to the PP2C family of Ser/Thr protein phosphatases. Members of PP2C family are negative regulators of cell stress response pathways and the MAP kinases and MAP kinase kinases. It has also been demonstrated to inhibit the activation of p38 and JNK kinase cascades. PPM1A dephosphorylates and promotes nuclear export of TGFbeta-activated Smad2/3. Ectopic expression of PPM1A abolishes TGFbeta-induced antiproliferative and transcriptional responses, whereas depletion of PPM1A enhances TGFbeta signaling in mammalian cells. It has been demonstrated that PPM1A/PP2CA, through dephosphorylation of Smad2/3, plays a critical role in terminating TGFbeta signaling. Overexpression of PPM1A is reported to activate the expression of the tumor suppressor gene TP53/p53, which leads to cell apoptosis. Protein function: Enzyme with a broad specificity. Negatively regulates TGF- beta signaling through dephosphorylating SMAD2 and SMAD3, resulting in their dissociation from SMAD4, nuclear export of the SMADs and termination of the TGF-beta-mediated signaling. Dephosphorylates PRKAA1 and PRKAA2. Plays an important role in the termination of TNF-alpha-mediated NF-kappa-B activation through dephosphorylating and inactivating IKBKB/IKKB. [The UniProt Consortium]