Anti-Recombinant Non-Phospho (Active) beta-Catenin (Ser33, Ser37, Thr41), clone A593

beta-catenin is a key downstream effector in the Wnt signaling pathway. It is implicated in two major biological processes in vertebrates: early embryonic development and tumorigenesis. CK1 phosphorylates beta-catenin at Ser45. This phosphorylation event primes beta-catenin for subsequent phosphorylation by GSK-3beta. GSK-3beta destabilizes beta-catenin by phosphorylating it at Ser33, Ser37, and Thr41. Mutations at these sites result in the stabilization of beta-catenin protein levels and have been found in many tumor cell lines.Non-phospho (Active) beta-Catenin (Ser33/37/Thr41) Rabbit mAb specifically recognizes beta-catenin that is non-phosphorylated at Ser33, Ser33 or Thr41. Non-phospho beta-Catenin (Ser33, Ser33 or Thr41) protein is useful as a readout of stabilized beta-catenin protein, and therefore functionally active in cell-cell adhesion and mediating transcriptional activity via the canonical Wnt signaling pathway.