Anti-Recombinant FOXC1, clone A663

FoxC1, also named as FKHL7 or FREAC3, is one of two mammalian FoxC subfamily members. Along with FoxC2, it is expressed in paraxial mesoderm where it functions to promote somitogenesis, myogenesis, and vascular development, possibly under Wnt/beta-catenin regulation. Mutations in FoxC1 are implicated in anterior segment dysgenesis (ASD) disorders, including congenital glaucoma and Axenfeld-Rieger syndrome. Research studies have shown that alterations in FoxC1 expression are linked to breast cancer invasiveness and have been shown to modulate proliferation and migration of breast cancer cells in vitro.