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NEW
| Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
|---|---|---|---|---|---|---|---|
| E-AN302948L.50 | 50 µl | - | - |
10 - 15 business days* |
171.00€
|
||
| E-AN302948L.100 | 100 µl | - | - |
10 - 15 business days* |
259.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Protein function: A cytochrome P450 monooxygenase involved in vitamin D metabolism and in calcium... more
Product information "Anti-Recombinant CP27B, clone C112568"
Protein function: A cytochrome P450 monooxygenase involved in vitamin D metabolism and in calcium and phosphorus homeostasis. Catalyzes the rate-limiting step in the activation of vitamin D in the kidney, namely the hydroxylation of 25-hydroxyvitamin D3/calcidiol at the C1alpha-position to form the hormonally active form of vitamin D3, 1alpha,25-dihydroxyvitamin D3/calcitriol that acts via the vitamin D receptor (VDR) (PubMed:10518789, PubMed:10566658, PubMed:12050193, PubMed:22862690, PubMed:9486994). Has 1alpha-hydroxylase activity on vitamin D intermediates of the CYP24A1-mediated inactivation pathway (PubMed:10518789, PubMed:22862690). Converts 24R,25-dihydroxyvitamin D3/secalciferol to 1-alpha,24,25-trihydroxyvitamin D3, an active ligand of VDR. Also active on 25-hydroxyvitamin D2 (PubMed:10518789). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via FDXR/adrenodoxin reductase and FDX1/adrenodoxin (PubMed:22862690) [The UniProt Consortium]
| Keywords: | Anti-CYP27B1, Anti-Cytochrome p450 27B1, Anti-Cytochrome P450C1 alpha, Anti-Cytochrome P450VD1-alpha, Anti-Calcidiol 1-monooxygenase, Anti-25-OHD-1 alpha-hydroxylase, Anti-25-hydroxyvitamin D(3) 1-alpha-hydroxylase, Recombinant CP27B Monoclonal Antibody |
| Supplier: | Elabscience |
| Supplier-Nr: | E-AN302948L |
Properties
| Application: | WB, IHC, IF, IP, ELISA |
| Antibody Type: | Monoclonal |
| Clone: | C112568 |
| Conjugate: | No |
| Host: | Rabbit |
| Species reactivity: | human,mouse,rat |
| Format: | Purified |
Database Information
| KEGG ID : | K07438 | Matching products |
| UniProt ID : | O15528 | Matching products |
| Gene ID : | GeneID 1594 | Matching products |
Handling & Safety
| Storage: | -20°C |
| Shipping: | -20°C (International: -20°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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