Anti-RCOR1

Anti-RCOR1
Item number Size Datasheet Manual SDS Delivery time Quantity Price
E-AB-64348.60 60 µl -

7 - 16 business days*

198.00€
E-AB-64348.120 120 µl -

7 - 16 business days*

317.00€
E-AB-64348.200 200 µl -

7 - 16 business days*

525.00€
 
This gene encodes a protein that is well-conserved, downregulated at birth, and with a specific... more
Product information "Anti-RCOR1"
This gene encodes a protein that is well-conserved, downregulated at birth, and with a specific role in determining neural cell differentiation. The encoded protein binds to the C-terminal domain of REST (repressor element-1 silencing transcription factor). Protein function: Essential component of the BHC complex, a corepressor complex that represses transcription of neuron-specific genes in non-neuronal cells. The BHC complex is recruited at RE1/NRSE sites by REST and acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. In the BHC complex, it serves as a molecular beacon for the recruitment of molecular machinery, including MeCP2 and SUV39H1, that imposes silencing across a chromosomal interval. Plays a central role in demethylation of Lys-4 of histone H3 by promoting demethylase activity of KDM1A on core histones and nucleosomal substrates. It also protects KDM1A from the proteasome. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development and controls hematopoietic differentiation. [The UniProt Consortium]
Keywords: Anti-RCOR1, Anti-KIAA0071, Anti-Protein CoREST, Anti-REST corepressor 1, RCOR1 Polyclonal Antibody
Supplier: Elabscience
Supplier-Nr: E-AB-64348

Properties

Application: WB
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Species reactivity: human, mouse
Immunogen: Recombinant protein of human RCOR1

Handling & Safety

Storage: -20°C
Shipping: 4°C (International: -20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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