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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
NSJ-RQ7122 | 100 µg | - | - |
3 - 10 business days* |
755.00€
|
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You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
0.5mg/ml if reconstituted with 0.2ml sterile DI water. Regulator of Chromosome Condensation, also... more
Product information "Anti-RCC1 / Regulator of Chromosome Condensation, clone 7B5D2"
0.5mg/ml if reconstituted with 0.2ml sterile DI water. Regulator of Chromosome Condensation, also named RCC1, SNHG3-RCC1 and CHC1 (Chromosome condensation protein 1), promotes the exchange of ran-bound gdp by gtp. It is involved in the regulation of onset of chromosome condensation in the S-phase. Phosphorylation of RCC1 on serines located in or near its nuclear localization signal activates RCC1 to generate RanGTP on mitotic chromosomes, which is required for spindle assembly and chromosome segregation. Protein function: Guanine-nucleotide releasing factor that promotes the exchange of Ran-bound GDP by GTP, and thereby plays an important role in RAN-mediated functions in nuclear import and mitosis (PubMed:1944575, PubMed:17435751, PubMed:20668449, PubMed:22215983, PubMed:11336674). Contributes to the generation of high levels of chromosome-associated, GTP-bound RAN, which is important for mitotic spindle assembly and normal progress through mitosis (PubMed:12194828, PubMed:17435751, PubMed:22215983). Via its role in maintaining high levels of GTP-bound RAN in the nucleus, contributes to the release of cargo proteins from importins after nuclear import (PubMed:22215983). Involved in the regulation of onset of chromosome condensation in the S phase (PubMed:3678831). Binds both to the nucleosomes and double- stranded DNA (PubMed:17435751, PubMed:18762580). [The UniProt Consortium]
Keywords: | Anti-CHC1, Anti-RCC1, Anti-Cell cycle regulatory protein, Anti-Chromosome condensation protein 1, Anti-Regulator of chromosome condensation, RCC1 Antibody / Regulator of Chromosome Condensation |
Supplier: | NSJ Bioreagents |
Supplier-Nr: | RQ7122 |
Properties
Application: | WB |
Antibody Type: | Monoclonal |
Clone: | 7B5D2 |
Conjugate: | No |
Host: | Mouse |
Species reactivity: | human |
Immunogen: | Recombinant human protein (amino acids A14-S421) |
Format: | Purified |
Database Information
KEGG ID : | K11493 | Matching products |
UniProt ID : | P18754 | Matching products |
Gene ID | GeneID 1104 | Matching products |
Handling & Safety
Storage: | +4°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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