Anti-RBM12B / RNA-binding protein 12B

Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml. RBM12B antibody detects RNA-binding protein 12B, a member of the RNA recognition motif (RRM) family that plays key roles in post-transcriptional gene regulation, mRNA processing, and nuclear RNA metabolism. RBM12B is believed to participate in alternative splicing and transcript stability by binding specific RNA motifs, thereby influencing gene expression patterns across multiple tissues. The RBM12B antibody is widely used in molecular biology and RNA research to study nuclear RNA dynamics, splicing regulation, and transcriptional coupling.RBM12B is encoded by the RBM12B gene located on human chromosome 8q24.23. The protein is approximately 1,010 amino acids long and contains multiple RRM domains, each recognizing short RNA sequence elements. These RRMs are supported by intrinsically disordered regions that enable flexible interactions with other RNA-binding proteins and components of the spliceosome. RBM12B localizes primarily to the nucleus, where it forms speckle-like foci typical of splicing regulators.The RBM12B antibody detects a 110-130 kilodalton band by western blot and reveals nuclear punctate staining under immunofluorescence microscopy. RBM12B interacts with heterogeneous nuclear ribonucleoproteins (hnRNPs) and splicing factors such as SRSF1, influencing exon inclusion and mRNA diversity. Through these interactions, RBM12B contributes to fine-tuning of transcript variants essential for cell type-specific expression and developmental processes.Recent studies suggest RBM12B modulates gene expression linked to neuronal development and stress responses. Altered RBM12B expression has been reported in neurological disorders and cancer, where it affects transcriptome remodeling and mRNA turnover. Its paralog, RBM12, shares structural similarities, yet RBM12B may regulate distinct subsets of mRNAs, suggesting functional divergence within the family.As a multifunctional RNA-binding protein, RBM12B connects transcriptional output with RNA processing and export. NSJ Bioreagents provides a validated RBM12B antibody optimized for its applications, supporting research into mRNA processing, splicing regulation, and gene expression control.