Anti-Ras and Rab interactor 1 / RIN1

0.5mg/ml if reconstituted with 0.2ml sterile DI water. Ras and Rab interactor 1 is a protein that in humans is encoded by the RIN1 gene. Predicted to enable small GTPase binding activity. Predicted to be involved in endocytosis, regulation of catalytic activity, and signal transduction. Predicted to act upstream of or within associative learning, memory, and negative regulation of synaptic plasticity. Located in cytoplasm and plasma membrane. Protein function: Ras effector protein, which may serve as an inhibitory modulator of neuronal plasticity in aversive memory formation. Can affect Ras signaling at different levels. First, by competing with RAF1 protein for binding to activated Ras. Second, by enhancing signaling from ABL1 and ABL2, which regulate cytoskeletal remodeling. Third, by activating RAB5A, possibly by functioning as a guanine nucleotide exchange factor (GEF) for RAB5A, by exchanging bound GDP for free GTP, and facilitating Ras-activated receptor endocytosis. [The UniProt Consortium]