Anti-RARS2 / Arginyl-tRNA synthetase 2

Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml. RARS2 antibody detects Arginyl-tRNA synthetase 2, mitochondrial, an enzyme that catalyzes the attachment of arginine to its corresponding mitochondrial tRNA during protein synthesis. RARS2 plays a critical role in maintaining mitochondrial translation and respiratory chain function. The RARS2 antibody is used in mitochondrial biology, genetics, and neurodegenerative research to study mitochondrial protein synthesis and energy metabolism.RARS2 is encoded by the RARS2 gene located on human chromosome 6q16.1. The protein is approximately 580 amino acids long and localizes to the mitochondrial matrix, where it contributes to the translation of 13 essential oxidative phosphorylation (OXPHOS) subunits encoded by mitochondrial DNA. RARS2 functions as part of the aminoacyl-tRNA synthetase family, ensuring fidelity of tRNA charging for mitochondrial translation.The RARS2 antibody detects a 65 kilodalton protein by western blot and reveals mitochondrial localization under confocal imaging. RARS2 ensures accurate incorporation of arginine during protein synthesis, maintaining the stoichiometry of respiratory chain complexes. Loss of RARS2 activity disrupts mitochondrial protein translation, leading to decreased OXPHOS efficiency and increased oxidative stress.Mutations in RARS2 cause pontocerebellar hypoplasia type 6, a neurodegenerative disorder characterized by developmental delay, seizures, and cerebellar atrophy. In cellular models, depletion of RARS2 impairs mitochondrial respiration, ATP production, and neuronal viability. Its regulation is closely tied to mitochondrial biogenesis and stress adaptation.As an essential enzyme for mitochondrial translation and neural health, RARS2 is a valuable model for understanding mitochondrial gene expression and energy homeostasis. NSJ Bioreagents provides a validated RARS2 antibody optimized for its applications, supporting studies in mitochondrial translation, metabolic regulation, and neurodegenerative disease mechanisms.