Anti-RAIN

function:May act as effector for Golgi-bound HRAS and other Ras-like proteins. May promote HRAS-mediated transformation.,similarity:Contains 1 dilute domain.,similarity:Contains 1 Ras-associating domain.,subcellular location:Associated with perinuclear vesicles. Is recruited to Golgi stacks by activated HRAS.,subunit:Interacts with Ras family members that have been activated by GTP binding. Interacts with HRAS, RAP1A, RAP2, RRAS, RAF1 and RRAS2.,tissue specificity:Highly expressed in heart. Detected at lower levels in placenta and pancreas., Protein function: Required for the proper formation of vascular structures that develop via both vasculogenesis and angiogenesis. Acts as a critical and vascular-specific regulator of GTPase signaling, cell architecture, and adhesion, which is essential for endothelial cell morphogenesis and blood vessel tubulogenesis. Regulates the activity of Rho GTPases in part by recruiting ARHGAP29 and suppressing RhoA signaling and dampening ROCK and MYH9 activities in endothelial cells. May act as effector for Golgi-bound HRAS and other Ras- like proteins. May promote HRAS-mediated transformation. Negative regulator of amino acid starvation-induced autophagy. [The UniProt Consortium] Recommended dilutions: WB 1:500-2000 ELISA 1:5000-20000. Cellular localization: Cytoplasm, perinuclear region . Golgi apparatus, Golgi stack . Associated with perinuclear vesicles. Is recruited to Golgi stacks by activated HRAS.