Anti-RAF1/c-RAF

Anti-RAF1/c-RAF
Item number Size Datasheet Manual SDS Delivery time Quantity Price
A301-519A-T 20 µl (2 blots) -

3 - 9 business days*

131.00€
A301-519A-M 100 µl (10 blots) -

3 - 9 business days*

313.00€
A301-519A 100 µl (20 µg) -

3 - 9 business days*

465.00€
 
Protein function: Serine/threonine-protein kinase that acts as a regulatory link between the... more
Product information "Anti-RAF1/c-RAF"
Protein function: Serine/threonine-protein kinase that acts as a regulatory link between the membrane-associated Ras GTPases and the MAPK/ERK cascade, and this critical regulatory link functions as a switch determining cell fate decisions including proliferation, differentiation, apoptosis, survival and oncogenic transformation. RAF1 activation initiates a mitogen-activated protein kinase (MAPK) cascade that comprises a sequential phosphorylation of the dual-specific MAPK kinases (MAP2K1/MEK1 and MAP2K2/MEK2) and the extracellular signal-regulated kinases (MAPK3/ERK1 and MAPK1/ERK2). The phosphorylated form of RAF1 (on residues Ser-338 and Ser-339, by PAK1) phosphorylates BAD/Bcl2- antagonist of cell death at 'Ser-75'. Phosphorylates adenylyl cyclases: ADCY2, ADCY5 and ADCY6, resulting in their activation. Phosphorylates PPP1R12A resulting in inhibition of the phosphatase activity. Phosphorylates TNNT2/cardiac muscle troponin T. Can promote NF-kB activation and inhibit signal transducers involved in motility (ROCK2), apoptosis (MAP3K5/ASK1 and STK3/MST2), proliferation and angiogenesis (RB1). Can protect cells from apoptosis also by translocating to the mitochondria where it binds BCL2 and displaces BAD/Bcl2-antagonist of cell death. Regulates Rho signaling and migration, and is required for normal wound healing. Plays a role in the oncogenic transformation of epithelial cells via repression of the TJ protein, occludin (OCLN) by inducing the up-regulation of a transcriptional repressor SNAI2/SLUG, which induces down-regulation of OCLN. Restricts caspase activation in response to selected stimuli, notably Fas stimulation, pathogen-mediated macrophage apoptosis, and erythroid differentiation. [The UniProt Consortium]
Keywords: Anti-RAF, Anti-RAF1, Anti-cRaf, Anti-Raf-1, EC=2.7.11.1, Anti-Proto-oncogene c-RAF, Anti-RAF proto-oncogene serine/threonine-protein kinase
Supplier: Bethyl Laboratories
Supplier-Nr: A301-519A

Properties

Application: WB, IP
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Reactivity: Human, Mouse (Expected: Rat, Bovine, Orangutan)
Immunogen: synthetic peptide. The epitope recognized by A301-519A-T maps to a region between residue 598 and 648 of human v-raf-1 murine leukemia viral oncogene homolog 1 using the numbering given in entry NP_002871.1 (GeneID 5894).
Format: Antigen Affinity Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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