Anti-Rad9 (IHC)

Anti-Rad9 (IHC)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
IHC-00376-T 10 µl (5+ slides) -

3 - 9 business days*

131.00€
IHC-00376 100 µl (50+ slides) -

3 - 9 business days*

493.00€
 
Protein function: Component of the 9-1-1 cell-cycle checkpoint response complex that plays a... more
Product information "Anti-Rad9 (IHC)"
Protein function: Component of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair. The 9-1-1 complex is recruited to DNA lesion upon damage by the RAD17-replication factor C (RFC) clamp loader complex. Acts then as a sliding clamp platform on DNA for several proteins involved in long-patch base excision repair (LP-BER). The 9-1-1 complex stimulates DNA polymerase beta (POLB) activity by increasing its affinity for the 3'-OH end of the primer-template and stabilizes POLB to those sites where LP-BER proceeds, endonuclease FEN1 cleavage activity on substrates with double, nick, or gap flaps of distinct sequences and lengths, and DNA ligase I (LIG1) on long-patch base excision repair substrates. The 9-1-1 complex is necessary for the recruitment of RHNO1 to sites of double-stranded breaks (DSB) occurring during the S phase. RAD9A possesses 3'->5' double stranded DNA exonuclease activity. Its phosphorylation by PRKCD may be required for the formation of the 9-1-1 complex. [The UniProt Consortium]
Keywords: Anti-RAD9A, Anti-hRAD9, EC=3.1.11.2, Anti-DNA repair exonuclease rad9 homolog A, Anti-Cell cycle checkpoint control protein RAD9A
Supplier: Bethyl Laboratories
Supplier-Nr: IHC-00376

Properties

Application: IHC, IHC-IF
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Reactivity: Human (Expected: Bovine, Dog, Swine, Panda, Rhesus Monkey, Gorilla, White-tufted-ear Marmoset, Crab-eating Macaque, European Domestic Ferret, Small-eared Galago, Little Brown Bat, Northern White-cheeked Gibbon)
Immunogen: synthetic peptide. The epitope recognized by IHC-00376 maps to a region between residue 350 and the C-terminus (residue 391) of human Rad9 using the numbering given in entry NP_004575.1 (GeneID 5883).
Format: Antigen Affinity Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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