Anti-RAB29 / RAB7L1

In 1X PBS, pH 7.4, with 0.09% sodium azide and 50% glycerol. RAB7L1/RAB29 is involved in the movement of various molecules within cells, helping to maintain their proper function and organization. It is involvement in the endocytic pathway, where it helps to ensure that molecules are transported to the correct destination within the cell. This process is crucial for maintaining cellular homeostasis and responding to external signals. RAB29 also plays a critical role in autophagy, a process in which cells degrade and recycle damaged or unnecessary components. By regulating the trafficking of autophagosomes, the structures responsible for engulfing and degrading cellular material, RAB29 helps to maintain cell viability and prevent the accumulation of toxic substances. In addition to its roles in cellular trafficking and recycling, RAB29 has also been implicated in various disease processes, including cancer and neurodegenerative disorders. Protein function: The small GTPases Rab are key regulators in vesicle trafficking (PubMed:24788816). Essential for maintaining the integrity of the endosome-trans-Golgi network structure. Together with LRRK2, plays a role in the retrograde trafficking pathway for recycling proteins, such as mannose 6 phosphate receptor (M6PR), between lysosomes and the Golgi apparatus in a retromer-dependent manner (PubMed:24788816). Recruits LRRK2 to the Golgi complex and stimulates LRRK2 kinase activity (PubMed:29212815, PubMed:38127736). Stimulates phosphorylation of RAB10 'Thr-73' by LRRK2 (PubMed:38127736). Regulates neuronal process morphology in the intact central nervous system (CNS). May play a role in the formation of typhoid toxin transport intermediates during Salmonella enterica serovar Typhi (S.typhi) epithelial cell infection (PubMed:22042847). [The UniProt Consortium]