Anti-Rab 34

This gene encodes a protein belonging to the RAB family of proteins, which are small GTPases involved in protein transport. This family member is a Golgi-bound member of the secretory pathway that is involved in the repositioning of lysosomes and the activation of macropinocytosis. Alternative splicing of this gene results in multiple transcript variants. This gene overlaps and shares exon structure with the nine-amino acid residue-repeats (NARR) gene, which encodes a functionally distinct nucleolar protein from a different reading frame. [provided by RefSeq, Jan 2012], Protein function: Transport protein involved in the redistribution of lysosomes to the peri-Golgi region (PubMed:27113757). Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis (PubMed:21255211). Plays a role in the fusion of phagosomes with lysosomes (PubMed:21255211). Acts also as a positive regulator of hedgehog signaling and regulates ciliary function. [The UniProt Consortium] Recommended dilutions: Western Blot: 1/500 - 1/2000.IHC-p 1:50-200 ELISA: 1/5000. Not yet tested in other applications.. Cellular localization: Cytoplasm . Golgi apparatus . Cytoplasmic vesicle, phagosome . Cytoplasmic vesicle, phagosome membrane , Lipid-anchor , Cytoplasmic side . Cell projection, cilium . Recruited to phagosomes containing S.aureus or M.tuberculosis (PubMed:21255211). .