Anti-QRICH1 / Glutamine-rich protein 1

Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml. QRICH1 antibody recognizes Glutamine-rich protein 1, a stress-responsive transcriptional regulator involved in the unfolded protein response, apoptosis, and cell differentiation. QRICH1 serves as a key mediator of endoplasmic reticulum (ER) stress adaptation by modulating gene expression in response to misfolded protein accumulation. The QRICH1 antibody is widely used in studies of ER stress signaling, apoptosis regulation, and differentiation processes that depend on transcriptional stress sensors.QRICH1 is encoded by the QRICH1 gene located on human chromosome 3q13.33. The protein is approximately 71 kilodaltons and characterized by an N-terminal glutamine-rich region that supports transcriptional activation and protein-protein interactions. QRICH1 functions downstream of the PERK-eIF2-alpha pathway during the integrated stress response. Under ER stress, phosphorylation of eIF2-alpha suppresses general translation but selectively promotes QRICH1 translation, leading to activation of genes involved in protein folding, lipid metabolism, and apoptosis suppression.The QRICH1 antibody enables detection of the protein by western blot, where it typically appears as a band around 86-100 kilodaltons. Immunofluorescence and confocal microscopy reveal predominant nuclear localization, consistent with its role as a transcriptional regulator. QRICH1 cooperates with transcriptional coactivators to regulate stress-responsive promoters and contributes to reprogramming during differentiation of osteoblasts, neurons, and epithelial cells. Knockdown experiments demonstrate that QRICH1 deficiency enhances sensitivity to ER stress-induced apoptosis, whereas overexpression supports cell survival by restoring proteostasis.Recent studies link QRICH1 to human skeletal dysplasia, where loss-of-function mutations impair osteoblast differentiation and bone matrix formation. Additionally, QRICH1 modulates lipid homeostasis and is involved in metabolic regulation under nutrient stress. It may also influence viral infection responses through control of translation reinitiation. NSJ Bioreagents provides a validated QRICH1 antibody optimized for western blot and flow cytometry, supporting investigations into transcriptional stress regulation, ER stress response, and cell differentiation mechanisms.