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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
P9452-45.100 | 100 µg | - | - |
3 - 19 business days* |
901.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Human Pygopus-1 (PYGO1, the name of a legless Australian lizard) is a 45kD, 419aa transcriptional... more
Product information "Anti-Pygopus Homolog 1 (Pygopus-1, PYGO1)"
Human Pygopus-1 (PYGO1, the name of a legless Australian lizard) is a 45kD, 419aa transcriptional coactivator. It contains four domains: an N-terminal NLS (aa35-41), followed by a Pro-rich, Asn-rich, and zinc-finger PHD-type domain (aa340-398). It is a nuclear protein that acts in concert with BCL-9 to retain b-catenin in the nucleus during Wnt-signaling. In particular, following b-catenin activation and translocation to the nucleus, b-catenin first binds to BCL-9 in a phosphorylation-independent manner. Its continued presence in the nucleus depends upon BCL-9 binding to Pygopus. Once anchored, b-catenin interacts with TCF to activate Wnt-responsive genes. Human Pygopus-1 is 87% aa identical to mouse Pygopus-1. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilutions: Western Blot: 1ug/ml , Optimal dilutions to be determined by the researcher. Storage and Stability: Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile PBS. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Keywords: | Anti-Pygopus homolog 1 |
Supplier: | United States Biological |
Supplier-Nr: | P9452-45 |
Properties
Application: | WB |
Antibody Type: | Monoclonal |
Clone: | 11C46 |
Conjugate: | No |
Host: | Mouse |
Species reactivity: | human, mouse |
Immunogen: | Purified, E.coli-derived recombinant human Pygopus-1 (aa1-419, Accession # Q9Y3Y4). |
Format: | Affinity Purified |
Database Information
UniProt ID : | Q9Y3Y4 | Matching products |
Gene ID | GeneID 26108 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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