Anti-PXDN / Peroxidasin

Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml. PXDN antibody detects Peroxidasin homolog, encoded by the PXDN gene on chromosome 2p25.3. PXDN antibody is widely used in studies of extracellular matrix biology, developmental processes, and disease mechanisms. PXDN is a multidomain peroxidase that contributes to extracellular matrix stabilization by catalyzing sulfilimine crosslinks in type IV collagen, a structural component of basement membranes. It is essential for tissue integrity and development of multiple organ systems.Structurally, PXDN is a large ~170 kDa secreted protein that contains leucine-rich repeats, immunoglobulin domains, and a peroxidase domain. This modular architecture allows interactions with extracellular matrix proteins and enzymatic activity. PXDN is localized to basement membranes in tissues such as kidney, lung, and vasculature. Alternative isoforms exist with different expression patterns, highlighting diverse tissue-specific roles.Functionally, PXDN stabilizes basement membranes by catalyzing sulfilimine bonds between methionine and hydroxylysine residues in collagen IV. This unique enzymatic activity reinforces structural integrity and mechanical strength of tissues. PXDN also participates in oxidative reactions, generating reactive intermediates that can influence cell signaling and immune responses. Researchers use PXDN antibody to study matrix biology, tissue development, and oxidative processes.Clinically, PXDN mutations cause congenital cataracts and developmental defects in kidney and lung, reflecting essential roles in basement membrane formation. Elevated PXDN expression has been linked to cancer progression, fibrosis, and cardiovascular disease. Autoantibodies against PXDN have been described in certain autoimmune conditions. Because of its role in extracellular matrix stabilization, PXDN is an emerging biomarker and therapeutic target. NSJ Bioreagents provides PXDN antibody to support research in development, oncology, and matrix biology.Experimentally, PXDN antibody is used in western blotting to detect the ~170 kDa protein, in immunohistochemistry to analyze basement membrane distribution, and in ELISA to measure PXDN levels in serum or conditioned media. Co-immunoprecipitation with PXDN antibody identifies collagen IV and matrix protein partners.