Anti-PTPN22

Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
ARG59377.100	100 µl		-	-	10 - 15 business days*		707.00€

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Protein function: Acts as negative regulator of T-cell receptor (TCR) signaling by direct... more

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Product information "Anti-PTPN22"

Protein function: Acts as negative regulator of T-cell receptor (TCR) signaling by direct dephosphorylation of the Src family kinases LCK and FYN, ITAMs of the TCRz/CD3 complex, as well as ZAP70, VAV, VCP and other key signaling molecules (PubMed:16461343, PubMed:18056643). Associates with and probably dephosphorylates CBL. Dephosphorylates LCK at its activating 'Tyr-394' residue (PubMed:21719704). Dephosphorylates ZAP70 at its activating 'Tyr- 493' residue (PubMed:16461343). Dephosphorylates the immune system activator SKAP2 (PubMed:21719704). Positively regulates toll-like receptor (TLR)-induced type 1 interferon production (PubMed:23871208). Promotes host antiviral responses mediated by type 1 interferon. Regulates NOD2-induced pro- inflammatory cytokine secretion and autophagy (PubMed:23991106). [The UniProt Consortium]

Keywords:	Anti-PEP, Anti-LyP, Anti-PTPN8, Anti-PTPN22, Anti-Lymphoid phosphatase, Anti-PEST-domain phosphatase, Anti-Tyrosine-protein phosphatase non-receptor type 22, Anti-Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP
Supplier:	Arigo Biolaboratories
Supplier-Nr:	ARG59377

Properties

Application:	WB
Antibody Type:	Polyclonal
Conjugate:	No
Host:	Rabbit
Species reactivity:	human, mouse
Immunogen:	Recombinant fusion protein corresponding to aa. 1-90 of Human PTPN22 (NP_036543.4)
MW:	92 kD
Format:	Affinity Purified