Anti-PTPN22

Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
ARG45126.50	50 µg		-	-	10 - 15 business days*		501.00€

If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk

Protein function: Acts as negative regulator of T-cell receptor (TCR) signaling by direct... more

Close menu

Product information "Anti-PTPN22"

Protein function: Acts as negative regulator of T-cell receptor (TCR) signaling by direct dephosphorylation of the Src family kinases LCK and FYN, ITAMs of the TCRz/CD3 complex, as well as ZAP70, VAV, VCP and other key signaling molecules. Associates with and probably dephosphorylates CBL. Dephosphorylates LCK at its activating 'Tyr-394' residue. Dephosphorylates ZAP70 at its activating 'Tyr-492' residue. Dephosphorylates the immune system activator SKAP2. Positively regulates toll-like receptor (TLR)-induced type 1 interferon production (PubMed:23871208). Promotes host antiviral responses mediated by type 1 interferon (PubMed:23871208). Regulates NOD2-induced pro-inflammatory cytokine secretion and autophagy (PubMed:23991106). Dephosphorylates phospho-anandamide (p-AEA), an endocannabinoid to anandamide (also called N-arachidonoylethanolamide) (PubMed:16938887). [The UniProt Consortium]

Keywords:	Anti-PEP, Anti-PEP, Anti-Ptpn8, Anti-Ptpn22, Anti-PEST-domain phosphatase, Anti-PEST-domain phosphatase, Anti-Tyrosine-protein phosphatase non-receptor type 22, Anti-Tyrosine-protein phosphatase non-receptor type 22, Anti-Hematopoietic cell protein-tyrosi
Supplier:	Arigo Biolaboratories
Supplier-Nr:	ARG45126

Properties

Application:	IHC (paraffin), WB
Antibody Type:	Polyclonal
Conjugate:	No
Host:	Rabbit
Species reactivity:	human, mouse, rat
Immunogen:	Recombinant protein containing to mouse PTPN22
MW:	90 kD
Format:	Antigen Affinity Purified