Anti-PTEN / Phosphatase and tensin

Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml. The PTEN antibody targets Phosphatase and tensin homolog, a dual-specificity phosphatase encoded by the PTEN gene. This enzyme is one of the most frequently mutated tumor suppressors in human cancer and plays a crucial role in regulating cell growth, survival, and metabolism. Phosphatase and tensin homolog functions primarily as a lipid phosphatase, dephosphorylating phosphatidylinositol (3,4,5)-trisphosphate (PIP3) to phosphatidylinositol (4,5)-bisphosphate (PIP2), thereby antagonizing the PI3K-AKT signaling pathway. The PTEN antibody enables detection of this critical regulatory protein and supports research into tumor suppression, cell signaling, and metabolic control.Phosphatase and tensin homolog acts at the plasma membrane to regulate signal transduction and control downstream kinases that drive proliferation and survival. Loss of PTEN function results in constitutive activation of AKT and mTOR pathways, leading to uncontrolled cell growth and oncogenesis. The PTEN antibody allows visualization of protein expression across tissues, facilitating analysis of its localization in both cytoplasmic and nuclear compartments. Nuclear PTEN has additional roles in maintaining chromosomal stability and DNA repair, expanding its tumor-suppressive functions beyond lipid dephosphorylation.Mutations or deletions in the PTEN gene occur in many cancers, including glioblastoma, prostate, breast, and endometrial carcinomas. Germline PTEN mutations cause PTEN hamartoma tumor syndromes such as Cowden syndrome, characterized by benign and malignant tumor development. The PTEN antibody is widely used in diagnostic and research settings to assess expression loss and mutation effects in tumor samples. Detection of reduced PTEN levels by immunohistochemistry is an important indicator of dysregulated PI3K signaling and poor prognosis.In addition to tumor suppression, Phosphatase and tensin homolog regulates cellular processes such as migration, apoptosis, and metabolism. It influences insulin signaling, oxidative stress response, and stem cell renewal. The PTEN antibody supports mechanistic studies into these diverse biological roles and enables quantification of protein abundance in cultured cells and tissue models. By revealing PTEN localization and activation states, this antibody provides insight into how phosphorylation, ubiquitination, or oxidation modulate its function under physiological and stress conditions.NSJ Bioreagents supplies the PTEN antibody with validated specificity and reproducibility for applications including western blotting, immunofluorescence, and immunohistochemistry. It reliably detects endogenous PTEN across multiple species and cell lines. By supporting detailed examination of this key tumor suppressor, the PTEN antibody facilitates research into cell signaling, cancer biology, and therapeutic interventions aimed at restoring pathway balance and inhibiting tumor progression.