Anti-PSTPIP1 / PEST phosphatase-interacting protein 1

Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml. PSTPIP1 antibody detects Proline-serine-threonine phosphatase-interacting protein 1, a cytoskeletal adaptor protein that regulates actin dynamics, immune signaling, and inflammasome activation. PSTPIP1 is primarily expressed in hematopoietic cells, where it interacts with the actin cytoskeleton and tyrosine phosphatases to coordinate immune cell morphology and migration. The PSTPIP1 antibody is extensively used in immunology and inflammation research to study cytoskeletal remodeling and autoinflammatory disease mechanisms.PSTPIP1 is encoded by the PSTPIP1 gene located on human chromosome 15q24.3. The protein belongs to the F-BAR domain-containing family and features an N-terminal F-BAR domain that mediates membrane curvature and actin binding, along with a C-terminal SH3 domain that interacts with proline-rich regions in partner proteins such as PEST-type tyrosine phosphatases and pyrin. Through these interactions, PSTPIP1 regulates membrane deformation, phagocytosis, and signaling cascades in macrophages and neutrophils.The PSTPIP1 antibody typically detects a 48-52 kilodalton protein by western blot and produces strong cytoplasmic and membrane-associated staining in immune cells. Functionally, PSTPIP1 links the actin cytoskeleton to signaling complexes, modulating processes such as cell spreading, migration, and inflammasome assembly. Mutations in PSTPIP1 are associated with PAPA (pyogenic arthritis, pyoderma gangrenosum, and acne) syndrome and other autoinflammatory disorders, where altered protein-protein interactions lead to hyperactivation of the pyrin inflammasome and excessive interleukin-1 beta production.PSTPIP1 interacts with proteins including WASP, c-Abl kinase, and SHIP1, integrating actin dynamics with immune receptor signaling. In macrophages, it contributes to the formation of podosomes and phagocytic structures. Beyond immune regulation, PSTPIP1 participates in bone remodeling and osteoclast differentiation through cytoskeletal control. NSJ Bioreagents provides a validated PSTPIP1 antibody optimized for western blot, immunoprecipitation, and immunofluorescence applications. This antibody supports research into inflammatory signaling, actin organization, and the molecular mechanisms underlying autoinflammatory diseases.