Anti-PSMD10 / Gankyrin

Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml. The PSMD10 antibody targets 26S proteasome non-ATPase regulatory subunit 10, also known as Gankyrin. Encoded by the PSMD10 gene, this oncoprotein functions as a regulatory component of the 19S proteasome and as an adaptor in cell cycle and tumor signaling. 26S proteasome non-ATPase regulatory subunit 10 promotes degradation of key regulatory proteins, including p53 and retinoblastoma protein (Rb), thereby influencing cell proliferation, differentiation, and oncogenic transformation. The PSMD10 antibody provides a powerful reagent for investigating proteasome dynamics, tumorigenesis, and protein degradation mechanisms.Gankyrin contains multiple ankyrin repeats that mediate protein-protein interactions with proteasome subunits and cell cycle regulators. It associates with CDK4, MDM2, and the 26S proteasome base complex to coordinate protein turnover. By enhancing MDM2-mediated ubiquitination of p53, 26S proteasome non-ATPase regulatory subunit 10 reduces tumor suppressor activity and contributes to cellular transformation. The PSMD10 antibody enables direct detection of Gankyrin expression in tumor tissues and cultured cells, supporting studies of its oncogenic potential and correlation with clinical outcomes.Overexpression of Gankyrin has been observed in numerous cancers, including hepatocellular carcinoma, colorectal carcinoma, and breast cancer. It accelerates cell cycle progression, promotes resistance to apoptosis, and enhances metastatic potential. The PSMD10 antibody allows researchers to quantify expression levels and subcellular localization of this protein, helping elucidate its functional role in oncogenic signaling pathways. Downregulation or inhibition of 26S proteasome non-ATPase regulatory subunit 10 has been shown to restore p53 stability and suppress tumor growth, making it an appealing therapeutic target.Beyond its oncogenic properties, Gankyrin contributes to proteasome assembly and quality control. It stabilizes interactions between ATPase and non-ATPase subunits of the 19S regulatory particle, facilitating efficient protein degradation. The PSMD10 antibody is suitable for western blotting, immunoprecipitation, and immunohistochemistry, allowing characterization of proteasomal function in normal and malignant cells. Its application extends to studies of proteostasis, cell cycle control, and ubiquitin-mediated degradation pathways.NSJ Bioreagents provides the PSMD10 antibody to ensure consistent detection of 26S proteasome non-ATPase regulatory subunit 10 across diverse experimental models. This reagent is instrumental for cancer researchers exploring Gankyrin's interactions with p53, Rb, and MDM2, as well as for cell biologists investigating proteasomal regulation. By delivering reproducible performance and high specificity, the PSMD10 antibody supports discovery in tumor biology and protein degradation research, illuminating mechanisms that link the proteasome to cell proliferation and oncogenesis.