Anti-PSA / Prostate Specific Antigen / KLK3, clone MSVA-603R

Antibody in 1X PBS with 0.05% BSA, 0.05% sodium azide. Prostate specific antigen (PSA), encoded by the KLK3 gene, is a secreted serine protease produced primarily by luminal epithelial cells of the prostate gland. PSA belongs to the kallikrein related peptidase family and is commonly referred to as kallikrein related peptidase 3. PSA Antibody for IHC is widely used for immunohistochemistry detection of Prostate specific antigen in formalin-fixed paraffin-embedded tissues and is an established marker for identifying prostatic epithelial cells and tumors of prostatic origin.Immunohistochemistry staining for PSA typically demonstrates strong cytoplasmic and luminal signal in prostate glandular epithelial cells, reflecting the secretory nature of the PSA protein. In benign prostate tissue, PSA staining highlights the luminal epithelial layer of prostatic glands while surrounding stromal cells remain negative. This distinct staining pattern allows clear visualization of prostate gland architecture in FFPE tissue sections.PSA expression is frequently retained in prostate adenocarcinoma, making PSA immunohistochemistry a widely used marker for confirming prostatic lineage in tumor samples. Strong cytoplasmic staining is commonly observed in primary prostate carcinoma as well as metastatic prostate cancer involving lymph node, bone, or other distant tissues. Detection of PSA by immunohistochemistry therefore plays an important role in distinguishing metastatic prostate carcinoma from morphologically similar tumors arising in other organs.Because PSA expression is highly restricted to prostate epithelial cells, immunohistochemistry analysis using PSA antibodies typically shows minimal staining in non-prostatic tissues. This high tissue specificity makes PSA one of the most widely used markers in prostate pathology and tumor classification studies. Evaluation of PSA staining patterns in tissue microarrays and clinical tumor samples helps researchers investigate prostate tumor differentiation, metastasis, and prostate epithelial biology.A PSA Antibody for IHC such as clone MSVA-603R provides a recombinant rabbit monoclonal reagent optimized for immunohistochemistry detection of Prostate specific antigen in FFPE tissue sections. Immunohistochemistry staining typically reveals strong cytoplasmic and luminal PSA signal in prostate epithelial cells and prostate adenocarcinoma cells, supporting research applications focused on prostate tissue identification and tumor origin analysis.This antibody is also part of a broader collection of IHC antibodies validated by tissue microarray analysis, supporting consistent staining across normal and cancer tissues.