Anti-PSA (human), Rabbit Monoclonal (RM323) (Biotin)

Prostate-specific antigen (PSA) is a chymotrypsin-like serine protease (kallikrein family) produced by the prostate epithelium and is abundant in seminal fluid. PSA can be detected in the sera of patients with prostatic carcinoma. It is predominantly complexed to a liver-derived serine protease inhibitor, alpha-1-antichymotrypsin (ACT). A higher proportion of serum PSA is complexed to ACT in prostate cancer than in benign prostate hyperplasia. PSA is used to confirm prostatic acinar cell origin in primary and metastatic carcinoma and to rule out non-prostatic carcinoma mimics. Protein function: Hydrolyzes semenogelin-1 thus leading to the liquefaction of the seminal coagulum. [The UniProt Consortium]