Anti-Prostein / SLC45A3, clone MSVA-460R

Antibody in 1X PBS with 0.05% BSA, 0.05% sodium azide. Solute carrier family 45 member 3 (SLC45A3) is a prostate-specific protein encoded by the SLC45A3 gene and localized primarily to the Golgi apparatus in secretory epithelial cells. SLC45A3 Antibody for IHC is optimized for immunohistochemistry detection of Prostein in formalin-fixed, paraffin-embedded tissues, where it produces a distinct cytoplasmic and perinuclear staining pattern that reflects Golgi-associated localization in prostate epithelium. Clone MSVA-460R is a recombinant rabbit monoclonal antibody designed to provide consistent and high-contrast staining in tissue sections, supporting clear interpretation of epithelial cell morphology.SLC45A3 antibody, also referred to as Prostein antibody or prostate-specific androgen-regulated protein antibody, shows highly restricted expression in prostate tissue, with strong labeling of luminal epithelial cells and minimal background in non-prostatic tissues. This tissue specificity makes SLC45A3 Antibody for IHC particularly valuable for distinguishing prostate-derived cells in complex tissue environments, including tumor samples and metastatic lesions where tissue origin must be resolved with confidence.In immunohistochemistry workflows, SLC45A3 Antibody for IHC demonstrates robust and reproducible staining across human tissue microarray panels, including large-scale TMA studies and multi-tissue arrays containing diverse normal and cancer specimens. Within TMA sections, staining is consistently observed in prostate epithelial compartments while remaining absent or very low in unrelated tissues, reinforcing its role as a prostate-restricted marker. The ability to generate clean, interpretable staining across tissue microarrays enhances its utility in comparative studies, biomarker validation, and high-throughput tissue screening approaches.The SLC45A3 protein belongs to the solute carrier family and is associated with intracellular transport processes within the secretory pathway. Its Golgi localization is supported by co-localization with Golgi-resident proteins, and its function is linked to protein trafficking and processing in highly secretory epithelial cells. This biological context explains the characteristic perinuclear staining pattern observed in immunohistochemistry, which aligns with known Golgi distribution in prostate epithelial cells.SLC45A3 Antibody for IHC enables detailed visualization of prostate glandular architecture, including luminal epithelial layers and tumor-associated epithelial cells. In prostate cancer tissues, staining highlights epithelial cell populations with preserved cytoplasmic and perinuclear localization, supporting interpretation of tumor differentiation and tissue origin. The reproducibility of staining across tissue microarrays, combined with strong prostate specificity, makes this antibody a powerful tool for research applications involving prostate biology, tumor classification, and epithelial marker analysis.This antibody is also part of a broader collection of IHC antibodies validated by tissue microarray analysis, supporting consistent staining across normal and cancer tissues.