Anti-Procalcitonin (Calcitonin Precursor, Calcitonin Related Polypeptide alpha, Calcitonin-related P

Procalcitonin (PCT) is a 116aa residue peptide with molecular weight of about 13kD. PCT itself has no known hormonal activity. PCT belongs to a group of related proteins including calcitonin gene-related peptides I and II, amylin, adrenomodulin and calcitonin (CAPA peptide family). PCT, like other peptides of CAPA family, appears from the common precursor pre-procalcitonin consisting of 141aa by removal of 25aa from the N-terminus. PCT undergoes successive cleavages to form three molecules: N-terminal fragment (55aa), calcitonin (32aa) and katacalcin (21aa). Under normal metabolic conditions, PCT is only present in the C cells of the thyroid gland. In bacterial infection and sepsis, however, intact PCT is found in the blood and, more importantly, its level is related to the severity of bacterial sepsis. Today, PCT is considered to be one of the earliest and most specific markers of sepsis. , Applications:, Suitable for use in ELISA and Western Blot. Other applications not tested. Recommended Dilutions: Optimal dilutions to be determined by the researcher. Hybridoma: Sp2/0 myeloma cells with spleen cells from Balb/c mice. Matched Pair: Capture: P9005-26J, Detection: P9005-25G, Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.