Anti-PRKRA

Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
ATA-HPA034997.25	25 µl		-		3 - 8 business days*		330.00€
ATA-HPA034997.100	100 µl		-		3 - 8 business days*		463.00€

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Protein function: Activates EIF2AK2/PKR in the absence of double-stranded RNA (dsRNA), leading to... more

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Product information "Anti-PRKRA"

Protein function: Activates EIF2AK2/PKR in the absence of double-stranded RNA (dsRNA), leading to phosphorylation of EIF2S1/EFI2-alpha and inhibition of translation and induction of apoptosis. Required for siRNA production by DICER1 and for subsequent siRNA-mediated post- transcriptional gene silencing. Does not seem to be required for processing of pre-miRNA to miRNA by DICER1. Promotes UBC9-p53/TP53 association and sumoylation and phosphorylation of p53/TP53 at 'Lys- 386' at 'Ser-392' respectively and enhances its activity in a EIF2AK2/PKR-dependent manner. [The UniProt Consortium] Buffer: 40% glycerol and PBS (pH 7.2). 0.02% sodium azide is added as preservative. Highest antigen sequence identity to mouse: 100% and to rat: 100%

Keywords:	Anti-PACT, Anti-PRKRA, Anti-HSD-14, Anti-PKR-associated protein X, Anti-PKR-associating protein X, Anti-Protein activator of the interferon-induced protein kinase, Anti-Protein kinase, interferon-inducible double-stranded RNA-dependent activator
Supplier:	Atlas Antibodies
Supplier-Nr:	HPA034997

Properties

Application:	ICC, IHC, WB
Antibody Type:	Polyclonal
Conjugate:	No
Host:	Rabbit
Species reactivity:	human
Immunogen:	Recombinant Protein Epitope Signature Tag (PrEST) antigen sequence: KLAKHRAAEA AINILKANAS ICFAVPDPLM PDPSKQPKNQ LNPIGSLQEL AIHHGWRLPE YTLSQEGGPA HKREYTTICR LESFMETGK (ATA-APrEST89329)