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| Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
|---|---|---|---|---|---|---|---|
| A701-076-T | 20 µl | - |
2 - 8 business days* |
172.00€
|
|||
| A701-076 | 100 µl | - |
2 - 8 business days* |
652.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Protein Function: Substrate-recognition component of a Cul2-RING (CRL2) E3 ubiquitin-protein... more
Product information "Anti-PRAME Recombinant Monoclonal"
Protein Function: Substrate-recognition component of a Cul2-RING (CRL2) E3 ubiquitin-protein ligase complex, which mediates ubiquitination of target proteins, leading to their degradation (PubMed:21822215, PubMed:26138980). The CRL2(PRAME) complex mediates ubiquitination and degradation of truncated MSRB1/SEPX1 selenoproteins produced by failed UGA/Sec decoding (PubMed:26138980). In the nucleus, the CRL2(PRAME) complex is recruited to epigenetically and transcriptionally active promoter regions bound by nuclear transcription factor Y (NFY) and probably plays a role in chromstin regulation (PubMed:21822215). Functions as a transcriptional repressor, inhibiting the signaling of retinoic acid through the retinoic acid receptors RARA, RARB and RARG: prevents retinoic acid-induced cell proliferation arrest, differentiation and apoptosis (PubMed:16179254) [The Uniprot Consortium]
| Keywords: | Anti-PRAME, Anti-Opa-interacting protein 4, Anti-Preferentially expressed antigen of melanoma, Anti-Melanoma antigen preferentially expressed in tumors |
| Supplier: | Bethyl Laboratories |
| Supplier-Nr: | A701-076 |
Properties
| Application: | IHC |
| Antibody Type: | Monoclonal |
| Clone: | BLGR076 |
| Conjugate: | No |
| Host: | Rabbit |
| Species reactivity: | human |
| Format: | Antigen Affinity Purified |
Database Information
| KEGG ID : | K28155 | Matching products |
| UniProt ID : | P78395 | Matching products |
| Gene ID : | GeneID 23532 | Matching products |
Handling & Safety
| Storage: | +4°C |
| Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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You will get a certificate here
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