Anti-PPP4R2

Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
A300-838A-T	10 µl (2 µg)		-		2 - 8 business days*		164.00€
A300-838A	100 µl		-		2 - 8 business days*		588.00€

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Protein function: Regulatory subunit of serine/threonine-protein phosphatase 4 (PP4). May... more

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Product information "Anti-PPP4R2"

Protein function: Regulatory subunit of serine/threonine-protein phosphatase 4 (PP4). May regulate the activity of PPP4C at centrosomal microtubule organizing centers. Its interaction with the SMN complex leads to enhance the temporal localization of snRNPs, suggesting a role of PPP4C in maturation of spliceosomal snRNPs. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AFX phosphorylated on 'Ser-140' (gamma-H2AFX) generated during DNA replication and required for DNA double strand break repair. Mediates RPA2 dephosphorylation by recruiting PPP4C to RPA2 in a DNA damage-dependent manner. RPA2 dephosphorylation is required for the efficient RPA2-mediated recruitment of RAD51 to chromatin following double strand breaks, an essential step for DNA repair. [The UniProt Consortium]

Keywords:	Anti-SBBI57, Anti-PPP4R2, Anti-Serine/threonine-protein phosphatase 4 regulatory subunit 2
Supplier:	Bethyl Laboratories
Supplier-Nr:	A300-838A

Properties

Application:	WB, IP, IHC
Antibody Type:	Polyclonal
Conjugate:	No
Host:	Rabbit
Species reactivity:	human, mouse (Expected: orangutan)
Immunogen:	synthetic peptide. The epitope recognized by A300-838A-T maps to a region between residue 370 and the C-terminus (residue 417) of human Protein Phosphatase 4, Regulatory Subunit 2 using the numbering given in entry NP_777567.1 (GeneID 151987).
Format:	Antigen Affinity Purified