Anti-POMC

Item number Size Datasheet Manual SDS Delivery time Quantity Price
E-AB-12576.20 20 µl -

7 - 16 business days*

71.00€
E-AB-12576.60 60 µl -

7 - 16 business days*

143.00€
E-AB-12576.120 120 µl -

7 - 16 business days*

238.00€
E-AB-12576.200 200 µl -

7 - 16 business days*

396.00€
 
This gene encodes a polypeptide hormone precursor that undergoes extensive, tissue-specific,... more
Product information "Anti-POMC"
This gene encodes a polypeptide hormone precursor that undergoes extensive, tissue-specific, post-translational processing via cleavage by subtilisin-like enzymes known as prohormone convertases. There are eight potential cleavage sites within the polypeptide precursor and, depending on tissue type and the available convertases, processing may yield as many as ten biologically active peptides involved in diverse cellular functions. The encoded protein is synthesized mainly in corticotroph cells of the anterior pituitary where four cleavage sites are used, adrenocorticotrophin, essential for normal steroidogenesis and the maintenance of normal adrenal weight, and lipotropin beta are the major end products. In other tissues, including the hypothalamus, placenta, and epithelium, all cleavage sites may be used, giving rise to peptides with roles in pain and energy homeostasis, melanocyte stimulation, and immune modulation. These include several distinct melanotropins, lipotropins, and endorphins that are contained within the adrenocorticotrophin and beta-lipotropin peptides. Mutations in this gene have been associated with early onset obesity, adrenal insufficiency, and red hair pigmentation. Alternatively spliced transcript variants encoding the same protein have been described. Protein function: Corticotropin: Stimulates the adrenal glands to release cortisol. [The UniProt Consortium]
Keywords: Anti-POMC, POMC Polyclonal Antibody
Supplier: Elabscience
Supplier-Nr: E-AB-12576

Properties

Application: WB, IHC, ELISA
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Species reactivity: human, mouse
Immunogen: Synthetic peptide of human POMC
Format: Purified

Handling & Safety

Storage: -20°C
Shipping: 4°C (International: -20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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