Anti-PNPase

Anti-PNPase
Item number Size Datasheet Manual SDS Delivery time Quantity Price
A303-917A-T 20 µl (2 blots) -

3 - 9 business days*

131.00€
A303-917A-M 100 µl (10 blots) -

3 - 9 business days*

313.00€
A303-917A 100 µl (100 µg) -

3 - 9 business days*

465.00€
 
Protein function: RNA-binding protein implicated in numerous RNA metabolic processes. Catalyzes... more
Product information "Anti-PNPase"
Protein function: RNA-binding protein implicated in numerous RNA metabolic processes. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'-to-5' direction. Mitochondrial intermembrane factor with RNA-processing exoribonulease activity. Component of the mitochondrial degradosome (mtEXO) complex, that degrades 3' overhang double- stranded RNA with a 3'-to-5' directionality in an ATP-dependent manner. Required for correct processing and polyadenylation of mitochondrial mRNAs. Plays a role as a cytoplasmic RNA import factor that mediates the translocation of small RNA components, like the 5S RNA, the RNA subunit of ribonuclease P and the mitochondrial RNA-processing (MRP) RNA, into the mitochondrial matrix. Plays a role in mitochondrial morphogenesis and respiration, regulates the expression of the electron transport chain (ETC) components at the mRNA and protein levels. In the cytoplasm, shows a 3'-to-5' exoribonuclease mediating mRNA degradation activity, degrades c-myc mRNA upon treatment with IFNB1/IFN-beta, resulting in a growth arrest in melanoma cells. Regulates the stability of specific mature miRNAs in melanoma cells, specifically and selectively degrades miR-221, preferentially. Plays also a role in RNA cell surveillance by cleaning up oxidized RNAs. Binds to the RNA subunit of ribonuclease P, MRP RNA and miR-221 microRNA. [The UniProt Consortium]
Keywords: Anti-PNPT1, Anti-PNPASE, Anti-PNPase 1, EC=2.7.7.8, Anti-PNPase old-35, Anti-3'-5' RNA exonuclease OLD35, Anti-Polynucleotide phosphorylase 1, Anti-Polynucleotide phosphorylase-like protein, Anti-Polyribonucleotide nucleotidyltransferase 1, mitochondrial
Supplier: Bethyl Laboratories
Supplier-Nr: A303-917A

Properties

Application: WB, IP
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Reactivity: Human (Expected: Mouse)
Immunogen: synthetic peptide. The epitope recognized by A303-917A-T maps to a region between residue 700 and 750 of human Polynucleotide Phosphorylase 1 using the numbering given in entry NP_149100.2 (GeneID 87178).
Format: Antigen Affinity Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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