Anti-PLXNB2 / Plexin B2

Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml. PLXNB2 antibody detects Plexin-B2, encoded by the PLXNB2 gene on chromosome 22q13.31. PLXNB2 antibody is used to study this large single-pass transmembrane receptor that belongs to the plexin family of semaphorin receptors. Plexins mediate signaling triggered by semaphorins, a family of secreted and membrane-bound proteins critical for axon guidance, cell migration, immune regulation, and angiogenesis. PLXNB2 functions prominently in nervous system development, but it also contributes to cancer progression, immune responses, and vascular biology. Its expression is broad, with particularly high levels in the brain, kidney, placenta, and immune tissues.Structurally, PLXNB2 contains an extracellular sema domain that mediates ligand binding, followed by PSI and IPT domains that facilitate protein interactions. The transmembrane region anchors it in the plasma membrane, while the cytoplasmic domain contains a split GAP (GTPase-activating protein) domain. This GAP activity targets Rho family GTPases, enabling PLXNB2 to regulate actin cytoskeleton remodeling, cell adhesion, and motility. Through associations with receptors such as MET and integrins, PLXNB2 integrates semaphorin signals with growth factor and adhesion signaling networks.Functionally, PLXNB2 influences diverse biological processes. In the nervous system, PLXNB2 regulates axonal pathfinding and dendritic spine morphogenesis. In immune cells, it modulates migration, activation, and antigen presentation. PLXNB2 also contributes to angiogenesis by coordinating endothelial cell guidance and vessel branching. Knockout studies in mice demonstrate that PLXNB2 deficiency leads to embryonic lethality, underscoring its essential developmental role. Researchers use PLXNB2 antibody to evaluate its contribution to cell guidance, immune regulation, and vascular formation.Clinically, PLXNB2 is implicated in cancer. Overexpression is observed in glioblastoma, breast cancer, and colorectal cancer, where it promotes invasion, angiogenesis, and resistance to therapy. By interacting with c-MET and other oncogenic signaling pathways, PLXNB2 contributes to tumor progression and poor prognosis. Beyond cancer, mutations in PLXNB2 have been linked to congenital brain malformations and developmental disorders. Elevated PLXNB2 expression is also associated with autoimmune diseases, reflecting its role in immune regulation.Experimentally, PLXNB2 antibody is applied in western blotting to detect the ~205 kDa protein, in immunohistochemistry to assess tumor and tissue expression, and in immunofluorescence to visualize its localization at the plasma membrane. Immunoprecipitation with PLXNB2 antibody helps identify interacting partners including semaphorins and receptor tyrosine kinases. NSJ Bioreagents supplies PLXNB2 antibody as a validated tool for developmental biology, neuroscience, cancer research, and immunology.