Anti-PLM

Protein function: Associates with and regulates the activity of the sodium/potassium-transporting ATPase (NKA) which transports Na(+) out of the cell and K(+) into the cell. Inhibits NKA activity in its unphosphorylated state and stimulates activity when phosphorylated. Reduces glutathionylation of the NKA beta-1 subunit ATP1B1, thus reversing glutathionylation-mediated inhibition of ATP1B1. Contributes to female sexual development by maintaining the excitability of neurons which secrete gonadotropin-releasing hormone. [The UniProt Consortium] Recommended dilutions: WB 1:1000-2000. Cellular localization: Cell membrane, sarcolemma , Single-pass type I membrane protein . Apical cell membrane , Single-pass type I membrane protein . Membrane, caveola . Cell membrane, sarcolemma, T-tubule . Detected in the apical cell membrane in brain. In myocytes, localizes to sarcolemma, t-tubules and intercalated disks. .