Anti-PIWI-L1

Anti-PIWI-L1
Item number Size Datasheet Manual SDS Delivery time Quantity Price
600-401-DP2 100 µg - -

6 - 10 business days*

684.00€
 
Anti-PIWI-L1 Antibody was affinity purified from monospecific antiserum by immunoaffinity... more
Product information "Anti-PIWI-L1"
Anti-PIWI-L1 Antibody was affinity purified from monospecific antiserum by immunoaffinity chromatography. Cross reactivity with PIWI-L1 from other sources has not been determined. Protein function: Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Directly binds methylated piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements. Besides their function in transposable elements repression, piRNAs are probably involved in other processes during meiosis such as translation regulation. Probable component of some RISC complex, which mediates RNA cleavage and translational silencing. Also plays a role in the formation of chromatoid bodies and is required for some miRNAs stability. Isoform 3 may be a negative developmental regulator. [The UniProt Consortium]
Keywords: Anti-HIWI, Anti-PIWIL1, Anti-Piwi-like protein 1
Supplier: Rockland Immunochemicals
Supplier-Nr: 600-401-DP2

Properties

Application: ELISA, IHC, IFM, WB
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Species reactivity: human, mouse, rat
Immunogen: 18 amino acid synthetic peptide near the N-terminus of human PIWI-L1.
Format: Purified

Handling & Safety

Storage: -20°C
Shipping: -20°C (International: -20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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