Anti-PIP5K1B

Phosphatidylinositol-4-phosphate-5-kinase (PIPK) synthesizes phosphatidylinositol-4,5-bisphosphate, which regulates various processes including cell proliferation, survival, membrane trafficking, and cytoskeletal organization. The PIPK family is divided into type I, type II and type III . Each type of the PIPK family phosphorylate distinct substrates and they contain an activation loop, which determines their enzymatic specificity and subcellular targeting . The phosphatidylinositol-4-phosphate-5-kinase type I consists of three members, PIPK I å, ?, and ©, which are characterized by phosphorylating PI4P on the 5-hydroxyl . PIPK I å (designated PIPK I ? in mouse) is expressed in brain tissue . PIPK I ?, designated PIPK I a in mouse, is also called STM7. PIPK I © has two variants produced by alternative splicing which are expressed in lung, brain, and kidneys. Protein function: Participates in the biosynthesis of phosphatidylinositol 4,5-bisphosphate. Mediates RAC1-dependent reorganization of actin filaments. Contributes to the activation of PLD2. Together with PIP5K1A is required after stimulation of G-protein coupled receptors for stable platelet adhesion. [The UniProt Consortium]